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Generation and Characterisation of a Pax8-CreER(T2) Transgenic Line and a Slc22a6-CreER(T2) Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells

Genetically relevant mouse models need to recapitulate the hallmarks of human disease by permitting spatiotemporal gene targeting. This is especially important for replicating the biology of complex diseases like cancer, where genetic events occur in a sporadic fashion within developed somatic tissu...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Espana-Agusti, Judit, Zou, Xiangang, Wong, Kim, Fu, Beiyuan, Yang, Fengtang, Tuveson, David A., Adams, David J., Matakidou, Athena
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751286/
https://ncbi.nlm.nih.gov/pubmed/26866916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148055
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