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Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase

Activating mutations of human K-Ras proteins are among the most common oncogenic mutations, present in approximately 30% of all human cancers. Posttranslational modifications to K-Ras guide it to the plasma membrane and disruption of this localization inhibits the growth of Ras-driven cancers. The h...

詳細記述

保存先:
書誌詳細
出版年:Medchemcomm
主要な著者: Butler, Kyle V, Bohn, Kelsey, Hrycyna, Christine A., Jin, Jian
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990076/
https://ncbi.nlm.nih.gov/pubmed/27547295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C6MD00130K
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