Hhip haploinsufficiency sensitizes mice to age-related emphysema

Genetic variants in Hedgehog interacting protein (HHIP) have consistently been associated with the susceptibility to develop chronic obstructive pulmonary disease and pulmonary function levels, including the forced expiratory volume in 1 s (FEV(1)), in general population samples by genome-wide assoc...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Lao, Taotao, Jiang, Zhiqiang, Yun, Jeong, Qiu, Weiliang, Guo, Feng, Huang, Chunfang, Mancini, John Dominic, Gupta, Kushagra, Laucho-Contreras, Maria E., Naing, Zun Zar Chi, Zhang, Li, Perrella, Mark A., Owen, Caroline A., Silverman, Edwin K., Zhou, Xiaobo
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987811/
https://ncbi.nlm.nih.gov/pubmed/27444019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602342113
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