Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity.

Oncogene amplification has been observed in a broad spectrum of human tumors and has been associated with a poor prognosis for patients with several different types of malignancies. Importantly, at biopsy, the amplified genes localize to acentric extrachromosomal elements such as double-minute chrom...

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Main Authors: Von Hoff, D D, McGill, J R, Forseth, B J, Davidson, K K, Bradley, T P, Van Devanter, D R, Wahl, G M
Format: Artigo
Sprog:Inglês
Udgivet: 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC49877/
https://ncbi.nlm.nih.gov/pubmed/1518843
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