Induction of differentiation in HL60 cells by the reduction of extrachromosomally amplified c-myc.

Oncogene amplification in tumor cells results in the overexpression of proteins that confer a growth advantage in vitro and in vivo. Amplified oncogenes can reside intrachromosomally, within homogeneously staining regions (HSRs), or extrachromosomally, within double minute chromosomes (DMs). Since p...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Eckhardt, S G, Dai, A, Davidson, K K, Forseth, B J, Wahl, G M, Von Hoff, D D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44265/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8022834/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.14.6674
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