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Nontumorigenic squamous cell carcinoma line converted to tumorigenicity with methyl methanesulfonate without activation of HRAS or MYC.

Plasticity of human tumor populations could account for the reason why many tumorigenic human cell lines lose this feature when grown in culture. Methyl methanesulfonate (MMS) was used to convert premalignant squamous cell carcinoma (SCC) cell line SCC-83-01-82 to a malignant phenotype. The MMS-trea...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Milo, G E, Shuler, C, Kurian, P, French, B T, Mannix, D G, Noyes, I, Hollering, J, Sital, N, Schuller, D, Trewyn, R W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53455/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2406716/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.4.1268
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