Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity.

Oncogene amplification has been observed in a broad spectrum of human tumors and has been associated with a poor prognosis for patients with several different types of malignancies. Importantly, at biopsy, the amplified genes localize to acentric extrachromosomal elements such as double-minute chrom...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Von Hoff, D D, McGill, J R, Forseth, B J, Davidson, K K, Bradley, T P, Van Devanter, D R, Wahl, G M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49877/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1518843/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.17.8165
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