Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles

Autophagosome formation requires sequential translocation of autophagy-specific proteins to membranes enriched in PI3P and connected to the ER. Preceding this, the earliest autophagy-specific structure forming de novo is a small punctum of the ULK1 complex. The provenance of this structure and its m...

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Publicat a:Nat Commun
Autors principals: Karanasios, Eleftherios, Walker, Simon A., Okkenhaug, Hanneke, Manifava, Maria, Hummel, Eric, Zimmermann, Hans, Ahmed, Qashif, Domart, Marie-Charlotte, Collinson, Lucy, Ktistakis, Nicholas T.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987534/
https://ncbi.nlm.nih.gov/pubmed/27510922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12420
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