Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis

ULK1 and ULK2 are thought to be essential for initiating autophagy, and Ulk1/2-deficient mice die perinatally of autophagy-related defects. Therefore, we used a conditional-knockout approach to investigate the roles of ULK1/2 in the brain. Although the mice showed neuronal degeneration, the neurons...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Joo, Joung Hyuck, Wang, Bo, Frankel, Elisa, Ge, Liang, Xu, Lu, Iyengar, Rekha, Li-Harms, XiuJie, Wright, Christopher, Shaw, Timothy I., Lindsten, Tullia, Green, Douglas R., Peng, Junmin, Hendershot, Linda M., Kilic, Fusun, Sze, Ji Ying, Audhya, Anjon, Kundu, Mondira
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993601/
https://ncbi.nlm.nih.gov/pubmed/27203176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.020
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