Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming

Erasure of epigenetic memory is required to convert somatic cells towards pluripotency. Reactivation of the inactive X chromosome (Xi) has been used to model epigenetic reprogramming in mouse, but human studies are hampered by Xi epigenetic instability and difficulties in tracking partially reprogra...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Cantone, Irene, Bagci, Hakan, Dormann, Dirk, Dharmalingam, Gopuraja, Nesterova, Tatyana, Brockdorff, Neil, Rougeulle, Claire, Vallot, Celine, Heard, Edith, Chaligne, Ronan, Merkenschlager, Matthias, Fisher, Amanda G.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987517/
https://ncbi.nlm.nih.gov/pubmed/27507283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12354
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