Synthesis and Biological Evaluation of Indole-2-carboxamides Bearing Photoactivatable Functionalities as Novel Allosteric Modulators for the Cannabinoid CB1 Receptor

5-Chloro-3-ethyl-N-(4-(piperidin-1-yl)phenethyl)-1H–indole-2-carboxamide (ORG27569, 1) is a prototypical allosteric modulator for the cannabinoid CB1 receptor. Based on this indole-2-carboxamide scaffold, we designed and synthesized novel CB1 allosteric modulators that possess photoactivatable funct...

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Detaylı Bibliyografya
Yayımlandı:Eur J Med Chem
Asıl Yazarlar: Qiao, Chang-Jiang, Ali, Hamed I., Ahn, Kwang H., Kolluru, Srikanth, Kendall, Debra A., Lu, Dai
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987248/
https://ncbi.nlm.nih.gov/pubmed/27318976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2016.05.044
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