Enhanced Pulmonary Vascular and Alveolar Development via Prenatal Administration of a Slow-Release Synthetic Prostacyclin Agonist in Rat Fetal Lung Hypoplasia

Lung hypoplasia and pulmonary hypertension are the major causes of mortality in neonates with congenital diaphragmatic hernia (CDH). Although the prostaglandin pathway plays a pivotal role in lung development, the reported efficacy of postnatal prostaglandin agonist treatment is suboptimal. We hypot...

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Vydáno v:PLoS One
Hlavní autoři: Umeda, Satoshi, Miyagawa, Shigeru, Fukushima, Satsuki, Oda, Noriko, Saito, Atsuhiro, Sakai, Yoshiki, Sawa, Yoshiki, Okuyama, Hiroomi
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4987057/
https://ncbi.nlm.nih.gov/pubmed/27529478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161334
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