Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain

The CD95/Fas/APO-1 death-inducing signaling complex (DISC), comprising CD95, FADD, procaspase-8, procaspase-10, and c-FLIP, has a key role in apoptosis induction. Recently, it was demonstrated that procaspase-8 activation is driven by death effector domain (DED) chains at the DISC. Here, we analyzed...

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Dettagli Bibliografici
Pubblicato in:Cell Death Differ
Autori principali: Schleich, K, Buchbinder, J H, Pietkiewicz, S, Kähne, T, Warnken, U, Öztürk, S, Schnölzer, M, Naumann, M, Krammer, P H, Lavrik, I N
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4986640/
https://ncbi.nlm.nih.gov/pubmed/26494467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.137
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