Phosphatase Rtr1 Regulates Global Levels of Serine 5 RNA Polymerase II C-Terminal Domain Phosphorylation and Cotranscriptional Histone Methylation

In eukaryotes, the C-terminal domain (CTD) of Rpb1 contains a heptapeptide repeat sequence of (Y(1)S(2)P(3)T(4)S(5)P(6)S(7))(n) that undergoes reversible phosphorylation through the opposing action of kinases and phosphatases. Rtr1 is a conserved protein that colocalizes with RNA polymerase II (RNAP...

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Vydáno v:Mol Cell Biol
Hlavní autoři: Hunter, Gerald O., Fox, Melanie J., Smith-Kinnaman, Whitney R., Gogol, Madelaine, Fleharty, Brian, Mosley, Amber L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985930/
https://ncbi.nlm.nih.gov/pubmed/27247267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00870-15
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