Identification of inhibitors of the transmembrane protease FlaK of Methanococcus maripaludis

GxGD‐type intramembrane cleaving proteases (I‐CLiPs) form a family of proteolytic enzymes that feature an aspartate‐based catalytic mechanism. Yet, they structurally and functionally largely differ from the classical pepsin‐like aspartic proteases. Among them are the archaeal enzyme FlaK, processing...

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Publicat a:Microbiologyopen
Autors principals: Coburger, Ina, Schaub, Yvonne, Roeser, Dirk, Hardes, Kornelia, Maeder, Patrick, Klee, Nina, Steinmetzer, Torsten, Imhof, Diana, Diederich, Wibke E., Than, Manuel E.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985597/
https://ncbi.nlm.nih.gov/pubmed/27038342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mbo3.358
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