FOLH1/GCPII is elevated in IBD patients, and its inhibition ameliorates murine IBD abnormalities

Recent gene-profiling analyses showed significant upregulation of the folate hydrolase (FOLH1) gene in the affected intestinal mucosa of patients with inflammatory bowel disease (IBD). The FOLH1 gene encodes a type II transmembrane glycoprotein termed glutamate carboxypeptidase II (GCPII). To establ...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Rais, Rana, Jiang, Weiwei, Zhai, Huihong, Wozniak, Krystyna M., Stathis, Marigo, Hollinger, Kristen R., Thomas, Ajit G., Rojas, Camilo, Vornov, James J., Marohn, Michael, Li, Xuhang, Slusher, Barbara S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4985244/
https://ncbi.nlm.nih.gov/pubmed/27536732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88634
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