Preparation and In Vitro–In Vivo Evaluation of Sustained-Release Matrix Pellets of Capsaicin to Enhance the Oral Bioavailability

Capsaicin has multiple pharmacological activities including antioxidant, anticancer, and anti-inflammatory activities. However, its clinical application is limited due to its poor aqueous solubility, gastric irritation, and low oral bioavailability. This research was aimed at preparing sustained-rel...

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Bibliographic Details
Published in:AAPS PharmSciTech
Main Authors: Zhang, Ya, Huang, Zhimin, Omari-Siaw, E., Lu, Shuang, Zhu, Yuan, Jiang, Dongmei, Wang, Miaomiao, Yu, Jiangnan, Xu, Ximing, Zhang, Weiming
Format: Artigo
Language:Inglês
Published: Springer US 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984881/
https://ncbi.nlm.nih.gov/pubmed/26127010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-015-0352-7
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