Optimization and evaluation of Lisinopril mucoadhesive sustained release matrix pellets: In-vitro and ex-vivo studies

Lisinopril (LIS) is antihypertensive drug, classified as a class III drug with high water solubility and low permeability. To overcome the low permeability, 32 factorial designs aimed to formulate LIS as a sustained-release (LIS-SR) matrix pellet by extrusion/spheronization. Matrix pellets were comp...

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Main Authors: Modhi F. Alagili, Bushra T. AlQuadeib, Lubna Y. Ashri, Mohamed Abbas Ibrahim
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2023-08-01
Serier:Saudi Pharmaceutical Journal
Fag:
Lisinopril
Oral delivery
Pellets
Extrusion/spheronization
In vitro and ex vivo characterization
Online adgang:http://www.sciencedirect.com/science/article/pii/S1319016423001858
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