Two Polypyrimidine Tracts in Intron 4 of the Major Immediate Early Gene Are Critical for Gene Expression Switching from IE1 to IE2 and for Replication of Human Cytomegalovirus

The human cytomegalovirus (HCMV) major immediate early (MIE) gene is essential for viral replication. The most abundant products encoded by the MIE gene include IE1 and IE2. Genes of IE1 and IE2 share the MIE promoter (MIEP), the first 3 exons, and the first 2 introns. IE1 is expressed earlier than...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Hou, Wangheng, Torres, Lilith, Cruz-Cosme, Ruth, Arroyo, Fernando, Irizarry, Luis, Luciano, Dalia, Márquez, Arturo, Rivera, Leslie L., Sala, Antonio L., Luo, Min-hua, Tang, Qiyi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984657/
https://ncbi.nlm.nih.gov/pubmed/27252533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00837-16
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