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Two Polypyrimidine Tracts in Intron 4 of the Major Immediate Early Gene Are Critical for Gene Expression Switching from IE1 to IE2 and for Replication of Human Cytomegalovirus

The human cytomegalovirus (HCMV) major immediate early (MIE) gene is essential for viral replication. The most abundant products encoded by the MIE gene include IE1 and IE2. Genes of IE1 and IE2 share the MIE promoter (MIEP), the first 3 exons, and the first 2 introns. IE1 is expressed earlier than...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Hou, Wangheng, Torres, Lilith, Cruz-Cosme, Ruth, Arroyo, Fernando, Irizarry, Luis, Luciano, Dalia, Márquez, Arturo, Rivera, Leslie L., Sala, Antonio L., Luo, Min-hua, Tang, Qiyi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984657/
https://ncbi.nlm.nih.gov/pubmed/27252533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00837-16
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