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Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity

Eukaryotic mRNAs possess a methylated 5′-guanosine cap that is required for RNA stability, efficient translation, and protection from cell-intrinsic defenses. Many viruses use 5′ caps or other mechanisms to mimic a cap structure to limit detection of viral RNAs by intracellular innate sensors and to...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Case, James Brett, Ashbrook, Alison W., Dermody, Terence S., Denison, Mark R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984653/
https://ncbi.nlm.nih.gov/pubmed/27252528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00542-16
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