A Recombinant Respiratory Syncytial Virus Vaccine Candidate Attenuated by a Low-Fusion F Protein Is Immunogenic and Protective against Challenge in Cotton Rats

Although respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in infants, a safe and effective vaccine is not yet available. Live-attenuated vaccines (LAVs) are the most advanced vaccine candidates in RSV-naive infants. However, designing an LAV with appropria...

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Detalhes bibliográficos
Publicado no:J Virol
Principais autores: Rostad, Christina A., Stobart, Christopher C., Gilbert, Brian E., Pickles, Ray J., Hotard, Anne L., Meng, Jia, Blanco, Jorge C. G., Moin, Syed M., Graham, Barney S., Piedra, Pedro A., Moore, Martin L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984630/
https://ncbi.nlm.nih.gov/pubmed/27279612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00012-16
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