Deep Sequencing of the HIV-1 env Gene Reveals Discrete X4 Lineages and Linkage Disequilibrium between X4 and R5 Viruses in the V1/V2 and V3 Variable Regions

HIV-1 requires the CD4 receptor and a coreceptor (CCR5 [R5 phenotype] or CXCR4 [X4 phenotype]) to enter cells. Coreceptor tropism can be assessed by either phenotypic or genotypic analysis, the latter using bioinformatics algorithms to predict tropism based on the env V3 sequence. We used the Primer...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Zhou, Shuntai, Bednar, Maria M., Sturdevant, Christa B., Hauser, Blake M., Swanstrom, Ronald
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
Matèries:
Genetic Diversity and Evolution
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984628/
https://ncbi.nlm.nih.gov/pubmed/27226378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00441-16
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