Deep Sequencing of the HIV-1 env Gene Reveals Discrete X4 Lineages and Linkage Disequilibrium between X4 and R5 Viruses in the V1/V2 and V3 Variable Regions

HIV-1 requires the CD4 receptor and a coreceptor (CCR5 [R5 phenotype] or CXCR4 [X4 phenotype]) to enter cells. Coreceptor tropism can be assessed by either phenotypic or genotypic analysis, the latter using bioinformatics algorithms to predict tropism based on the env V3 sequence. We used the Primer...

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Vydáno v:J Virol
Hlavní autoři: Zhou, Shuntai, Bednar, Maria M., Sturdevant, Christa B., Hauser, Blake M., Swanstrom, Ronald
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Genetic Diversity and Evolution
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984628/
https://ncbi.nlm.nih.gov/pubmed/27226378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00441-16
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