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Deep Sequencing of the HIV-1 env Gene Reveals Discrete X4 Lineages and Linkage Disequilibrium between X4 and R5 Viruses in the V1/V2 and V3 Variable Regions

HIV-1 requires the CD4 receptor and a coreceptor (CCR5 [R5 phenotype] or CXCR4 [X4 phenotype]) to enter cells. Coreceptor tropism can be assessed by either phenotypic or genotypic analysis, the latter using bioinformatics algorithms to predict tropism based on the env V3 sequence. We used the Primer...

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書目詳細資料
發表在:J Virol
Main Authors: Zhou, Shuntai, Bednar, Maria M., Sturdevant, Christa B., Hauser, Blake M., Swanstrom, Ronald
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984628/
https://ncbi.nlm.nih.gov/pubmed/27226378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00441-16
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