Role of Conserved E2 Residue W420 in Receptor Binding and Hepatitis C Virus Infection

Hepatitis C virus (HCV) enters cells via interactions with several host factors, a key one being that between the viral E2 envelope glycoprotein and the CD81 receptor. We previously identified E2 tryptophan residue 420 (W420) as an essential CD81-binding residue. However, the importance of W420 in t...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Cowton, Vanessa M., Angus, Allan G. N., Cole, Sarah J., Markopoulou, Christina K., Owsianka, Ania, Dunlop, James I., Gardner, Deborah E., Krey, Thomas, Patel, Arvind H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4984626/
https://ncbi.nlm.nih.gov/pubmed/27279607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00685-16
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