Forkhead Box O member FOXO1 Regulates the Majority of Follicle-Stimulating Hormone Responsive Genes in Ovarian Granulosa Cells

FSH promotes maturation of ovarian follicles. One pathway activated by FSH in granulosa cells (GCs) is phosphatidylinositol-3 kinase/AKT. The AKT target FOXO1 is reported to function primarily as a repressor of FSH genes, including Ccnd2 and Inha. Based on its broad functions in other tissues, we hy...

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Publicado en:Mol Cell Endocrinol
Main Authors: Herndon, Maria K., Law, Nathan C., Donaubauer, Elyse M., Kyriss, Brandon, Hunzicker-Dunn, Mary
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983523/
https://ncbi.nlm.nih.gov/pubmed/27328024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2016.06.020
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