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GPER mediates the age-dependent upregulation of the myocardial endothelin system

AIMS: Cardiac aging is associated with progressive structural changes and functional impairment, such as left ventricular hypertrophy, fibrosis and diastolic dysfunction. Aging also increases myocardial activity of endothelin-1 (ET-1), a multifunctional peptide with growth-promoting and pro-fibrotic...

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Bibliografiske detaljer
Udgivet i:Life Sci
Main Authors: Meyer, Matthias R., Fredette, Natalie C., Sharma, Geetanjali, Barton, Matthias, Prossnitz, Eric R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983270/
https://ncbi.nlm.nih.gov/pubmed/26880534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2016.02.041
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