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GPER Regulates Endothelin-Dependent Vascular Tone and Intracellular Calcium

AIMS: An increase in intracellular vascular smooth muscle cell calcium concentration (VSMC [Ca(2+)](i)) is essential for endothelin-1 (ET-1)-induced vasoconstriction. Based on previous findings that activation of the G protein-coupled estrogen receptor (GPER) inhibits vasoconstriction in response to...

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Main Authors: Meyer, Matthias R., Field, Angela S., Kanagy, Nancy L., Barton, Matthias, Prossnitz, Eric R.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355219/
https://ncbi.nlm.nih.gov/pubmed/22326502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2012.01.007
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