A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification

BACKGROUND: Studying atherosclerotic calcification in vivo requires mouse models with genetic modifications. Previous studies showed that injection of recombinant adeno-associated virus vector (AAV) encoding a gain-of-function mutant PCSK9 into mice promotes atherosclerosis. AIM: We aim to study car...

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Detalhes bibliográficos
Publicado no:Atherosclerosis
Main Authors: Goettsch, Claudia, Hutcheson, Joshua D., Hagita, Sumihiko, Rogers, Maximillian A., Creager, Michael D., Pham, Tan, Choi, Jung, Mlynarchik, Andrew K, Pieper, Brett, Kjolby, Mads, Aikawa, Masanori, Aikawa, Elena
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983246/
https://ncbi.nlm.nih.gov/pubmed/27318830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2016.06.011
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