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Toxic Dopamine Metabolite DOPAL Forms an Unexpected Dicatechol Pyrrole Adduct with α-Synuclein’s Lysines
Parkinson’s disease has long been known to involve the loss of dopaminergic neurons in the substantia nigra and the coincidental appearance of Lewy bodies containing oligomerized forms of α-synuclein. The ‘catecholaldehyde hypothesis’ posits a causal link between these two central pathologies mediat...
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| Veröffentlicht in: | Angew Chem Int Ed Engl |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4983193/ https://ncbi.nlm.nih.gov/pubmed/27158766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201600277 |
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