PNA clamping-assisted fluorescence melting curve analysis for detecting EGFR and KRAS mutations in the circulating tumor DNA of patients with advanced non-small cell lung cancer

BACKGROUND: Circulating cell-free DNA (cfDNA) is emerging as a surrogate sample type for mutation analyses. To improve the clinical utility of cfDNA, we developed a sensitive peptide nucleic acid (PNA)-based method for analyzing EGFR and KRAS mutations in the plasma cfDNA of patients with advanced n...

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Vydáno v:BMC Cancer
Hlavní autoři: Han, Ji-Youn, Choi, Jae-Jin, Kim, Jin Young, Han, You Lim, Lee, Geon Kook
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4983013/
https://ncbi.nlm.nih.gov/pubmed/27519791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2678-2
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