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Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency

Induced pluripotent stem cells (iPSCs) represent an innovative source for the standardized in vitro generation of macrophages (Mφ). We here describe a robust and efficient protocol to obtain mature and functional Mφ from healthy as well as disease-specific murine iPSCs. With regard to morphology, su...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Mucci, Adele, Kunkiel, Jessica, Suzuki, Takuji, Brennig, Sebastian, Glage, Silke, Kühnel, Mark P., Ackermann, Mania, Happle, Christine, Kuhn, Alexandra, Schambach, Axel, Trapnell, Bruce C., Hansen, Gesine, Moritz, Thomas, Lachmann, Nico
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4982988/
https://ncbi.nlm.nih.gov/pubmed/27453007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.06.011
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