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Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency

Induced pluripotent stem cells (iPSCs) represent an innovative source for the standardized in vitro generation of macrophages (Mφ). We here describe a robust and efficient protocol to obtain mature and functional Mφ from healthy as well as disease-specific murine iPSCs. With regard to morphology, su...

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Principais autores: Adele Mucci, Jessica Kunkiel, Takuji Suzuki, Sebastian Brennig, Silke Glage, Mark P. Kühnel, Mania Ackermann, Christine Happle, Alexandra Kuhn, Axel Schambach, Bruce C. Trapnell, Gesine Hansen, Thomas Moritz, Nico Lachmann
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016-08-01
Serier:Stem Cell Reports
Fag:
macrophages
PAP
iPSC
disease modeling
hematopoiesis
Online adgang:http://www.sciencedirect.com/science/article/pii/S2213671116301035
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