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Mitochondrial DNA Mutations Increase in Early Stage Alzheimer’s Disease and are Inconsistent with Oxidative Damage
Mitochondrial dysfunction and oxidative damage are commonly associated with early stage Alzheimer’s disease (AD). The accumulation of somatic mutations in mitochondrial DNA (mtDNA) has been hypothesized to be a driver of these phenotypes, but the detection of increased mutation loads has been diffic...
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| Publicado en: | Ann Neurol |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4982791/ https://ncbi.nlm.nih.gov/pubmed/27315116 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24709 |
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