Soy phosphatidylinositol containing lipid nanoparticle prolongs the plasma survival and hemostatic efficacy of B-domain deleted recombinant canine Factor VIII in Hemophilia A dogs

Soy phosphatidylinositol (PI) containing lipid nanoparticles prolong plasma survival, improve hemostatic efficacy, and decrease immunogenicity of human B-domain deleted Factor VIII (BDD FVIII) in Hemophilia A (HA) mice. We hypothesize that PI associated BDD FVIII is more potent than the free protein...

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Veröffentlicht in:J Pharm Sci
Hauptverfasser: Shetty, Krithika A., Merricks, Elizabeth P., Raymer, Robin, Rigsbee, Natalie, Nichols, Timothy C, Balu-Iyer, Sathy V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4982397/
https://ncbi.nlm.nih.gov/pubmed/27372547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.05.023
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