Selective recognition and stabilization of new ligands targeting the potassium form of the human telomeric G-quadruplex DNA

The development of a ligand that is capable of distinguishing among the wide variety of G-quadruplex structures and targeting telomeres to treat cancer is particularly challenging. In this study, the ability of two anthraquinone telomerase inhibitors (NSC749235 and NSC764638) to target telomeric G-q...

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Udgivet i:Sci Rep
Main Authors: Lin, Yi-Hwa, Chuang, Show-Mei, Wu, Pei-Ching, Chen, Chun-Liang, Jeyachandran, Sivakamavalli, Lo, Shou-Chen, Huang, Hsu-Shan, Hou, Ming-Hon
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980623/
https://ncbi.nlm.nih.gov/pubmed/27511133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31019
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