Urothelium muscarinic activation phosphorylates CBS(Ser227) via cGMP/PKG pathway causing human bladder relaxation through H(2)S production

The urothelium modulates detrusor activity through releasing factors whose nature has not been clearly defined. Here we have investigated the involvement of H(2)S as possible mediator released downstream following muscarinic (M) activation, by using human bladder and urothelial T24 cell line. Carbac...

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Publicat a:Sci Rep
Autors principals: d’Emmanuele di Villa Bianca, Roberta, Mitidieri, Emma, Fusco, Ferdinando, Russo, Annapina, Pagliara, Valentina, Tramontano, Teresa, Donnarumma, Erminia, Mirone, Vincenzo, Cirino, Giuseppe, Russo, Giulia, Sorrentino, Raffaella
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980605/
https://ncbi.nlm.nih.gov/pubmed/27509878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31491
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