The caffeine-binding adenosine A(2A) receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

Caffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A(2A) receptor (A(2A)R), which is upregulated in the human forebrain of aged and Alzheimer’s disease (AD) patients. We have previously shown that an anti-A(2A)R therapy reverts age-like memory...

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發表在:Sci Rep
Main Authors: Batalha, Vânia L., Ferreira, Diana G., Coelho, Joana E., Valadas, Jorge S., Gomes, Rui, Temido-Ferreira, Mariana, Shmidt, Tatiana, Baqi, Younis, Buée, Luc, Müller, Christa E., Hamdane, Malika, Outeiro, Tiago F., Bader, Michael, Meijsing, Sebastiaan H., Sadri-Vakili, Ghazaleh, Blum, David, Lopes, Luísa V.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980603/
https://ncbi.nlm.nih.gov/pubmed/27510168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31493
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