The caffeine-binding adenosine A(2A) receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function

Caffeine is associated with procognitive effects in humans by counteracting overactivation of the adenosine A(2A) receptor (A(2A)R), which is upregulated in the human forebrain of aged and Alzheimer’s disease (AD) patients. We have previously shown that an anti-A(2A)R therapy reverts age-like memory...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Batalha, Vânia L., Ferreira, Diana G., Coelho, Joana E., Valadas, Jorge S., Gomes, Rui, Temido-Ferreira, Mariana, Shmidt, Tatiana, Baqi, Younis, Buée, Luc, Müller, Christa E., Hamdane, Malika, Outeiro, Tiago F., Bader, Michael, Meijsing, Sebastiaan H., Sadri-Vakili, Ghazaleh, Blum, David, Lopes, Luísa V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980603/
https://ncbi.nlm.nih.gov/pubmed/27510168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31493
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados