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The extracellular chaperone clusterin sequesters oligomeric forms of the Aβ(1–40) peptide

In recent genome-wide association studies, the extracellular chaperone protein, clusterin, has been identified as a novel risk factor in Alzheimer’s disease (AD). We have examined the interactions between clusterin and the AD-associated amyloid-β(1–40) peptide (Aβ(1–40)) which is prone to aggregate...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Narayan, Priyanka, Orte, Angel, Clarke, Richard W., Bolognesi, Benedetta, Hook, Sharon, Ganzinger, Kristina A., Meehan, Sarah, Wilson, Mark R., Dobson, Christopher M., Klenerman, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979993/
https://ncbi.nlm.nih.gov/pubmed/22179788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2191
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