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Synthesis of a deuterated probe for the confocal Raman microscopy imaging of squalenoyl nanomedicines

The synthesis of ω-di-(trideuteromethyl)-trisnorsqualenic acid has been achieved from natural squalene. The synthesis features the use of a Shapiro reaction of acetone-d(6) trisylhydrazone as a key step to implement the terminal isopropylidene-d(6) moiety. The obtained squalenic acid-d(6) has been c...

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Vydáno v:Beilstein J Org Chem
Hlavní autoři: Buchy, Eric, Vukosavljevic, Branko, Windbergs, Maike, Sobot, Dunja, Dejean, Camille, Mura, Simona, Couvreur, Patrick, Desmaële, Didier
Médium: Artigo
Jazyk:Inglês
Vydáno: Beilstein-Institut 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979966/
https://ncbi.nlm.nih.gov/pubmed/27559365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.12.109
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