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Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death
The mammalian target of rapamycin complex 1 (mTORC1) is a highly conserved protein complex regulating key pathways in cell growth. Hyperactivation of mTORC1 is implicated in numerous cancers, thus making it a potential broad-spectrum chemotherapeutic target. Here, we characterized how mTORC1 respond...
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| Publicado no: | Cell Death Discov |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4979510/ https://ncbi.nlm.nih.gov/pubmed/27551516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2016.24 |
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