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Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding.

Polar amino acids lying within three hydrophobic regions of the dopamine transporter (DAT) are analogous to those important for ligand recognition by catecholamine receptors. Possible functional significance of these amino acids was examined by expressing DAT cDNAs mutated in these polar residues. R...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kitayama, S, Shimada, S, Xu, H, Markham, L, Donovan, D M, Uhl, G R
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49795/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1502198/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.16.7782
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