Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding.

Polar amino acids lying within three hydrophobic regions of the dopamine transporter (DAT) are analogous to those important for ligand recognition by catecholamine receptors. Possible functional significance of these amino acids was examined by expressing DAT cDNAs mutated in these polar residues. R...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kitayama, S, Shimada, S, Xu, H, Markham, L, Donovan, D M, Uhl, G R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49795/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1502198/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.16.7782
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