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Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2

MAPK-activated protein kinase 2 (MK2) is a checkpoint kinase involved in the DNA damage response. MK2 inhibition enhances the efficacy of chemotherapeutic agents; however, whether MK2 inhibition alone, without concurrent chemotherapy, would attenuate survival of cancer cells has not been investigate...

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Vydáno v:Cell Death Discov
Hlavní autoři: Gurgis, FMS, Åkerfeldt, MC, Heng, B, Wong, C, Adams, S, Guillemin, GJ, Johns, TG, Chircop, M, Munoz, L
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979411/
https://ncbi.nlm.nih.gov/pubmed/27551460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2015.28
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