Adenovirus-human immunodeficiency virus (HIV) envelope recombinant vaccines elicit high-titered HIV-neutralizing antibodies in the dog model.

Recombinant human adenoviruses (Ads) (types 4, 5, and 7) expressing the HIV-1 envelope membrane glycoprotein (gp160) were tested for immunogenicity in the dog. Administration of recombinant Ad7-env by intratracheal inoculation resulted in a low serum antibody response to gp160, which developed over...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Natuk, R J, Chanda, P K, Lubeck, M D, Davis, A R, Wilhelm, J, Hjorth, R, Wade, M S, Bhat, B M, Mizutani, S, Lee, S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49794/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1502197/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.16.7777
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