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Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

Summary: Artificial glycan holes on recombinant Env-based vaccines occur when a potential N-linked glycosylation site (PNGS) is under-occupied, but not on their viral counterparts. Native-like SOSIP trimers, including clinical candidates, contain such holes in the glycan shield that induce strain-sp...

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Autori principali: Ronald Derking, Joel D. Allen, Christopher A. Cottrell, Kwinten Sliepen, Gemma E. Seabright, Wen-Hsin Lee, Yoann Aldon, Kimmo Rantalainen, Aleksandar Antanasijevic, Jeffrey Copps, Anila Yasmeen, Albert Cupo, Victor M. Cruz Portillo, Meliawati Poniman, Niki Bol, Patricia van der Woude, Steven W. de Taeye, Tom L.G.M. van den Kerkhof, P.J. Klasse, Gabriel Ozorowski, Marit J. van Gils, John P. Moore, Andrew B. Ward, Max Crispin, Rogier W. Sanders
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021-04-01
Serie:Cell Reports
Soggetti:
HIV-1 vaccine research
glycan occupancy
cryo-EM
mass spectrometry
Accesso online:http://www.sciencedirect.com/science/article/pii/S2211124721002473
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