Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics.

The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in HIV-1 vaccine research aimed at inducing bNAbs. W...

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Principais autores:	Alba Torrents de la Peña, Kimmo Rantalainen, Christopher A Cottrell, Joel D Allen, Marit J van Gils, Jonathan L Torres, Max Crispin, Rogier W Sanders, Andrew B Ward
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2019-07-01
coleção:	PLoS Pathogens
Acesso em linha:	https://doi.org/10.1371/journal.ppat.1007920
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