mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies

The HIV-1 envelope glycoprotein (Env) is the sole neutralizing determinant on the surface of the virus. The Env gp120 and gp41 subunits mediate receptor binding and membrane fusion and are generated from the gp160 precursor by cellular furins. This cleavage event is required for viral entry. One app...

Повний опис

Бібліографічні деталі

Автори:	Javier Guenaga, Mehrdad Alirezaei, Yu Feng, Mohamad-Gabriel Alameh, Wen-Hsin Lee, Sabyasachi Baboo, Jocelyn Cluff, Richard Wilson, Shridhar Bale, Gabriel Ozorowski, Paulo Lin, Ying Tam, Jolene K. Diedrich, John R. Yates, James C. Paulson, Andrew B. Ward, Drew Weissman, Richard T. Wyatt
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2024-07-01
Серія:	Frontiers in Immunology
Предмети:	HIV vaccine mRNA NFL SOSIP Env
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1426232/full
Теги:	Додати тег Немає тегів, Будьте першим, хто поставить тег для цього запису!