mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies

The HIV-1 envelope glycoprotein (Env) is the sole neutralizing determinant on the surface of the virus. The Env gp120 and gp41 subunits mediate receptor binding and membrane fusion and are generated from the gp160 precursor by cellular furins. This cleavage event is required for viral entry. One app...

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Detaylı Bibliyografya
Asıl Yazarlar:	Javier Guenaga, Mehrdad Alirezaei, Yu Feng, Mohamad-Gabriel Alameh, Wen-Hsin Lee, Sabyasachi Baboo, Jocelyn Cluff, Richard Wilson, Shridhar Bale, Gabriel Ozorowski, Paulo Lin, Ying Tam, Jolene K. Diedrich, John R. Yates, James C. Paulson, Andrew B. Ward, Drew Weissman, Richard T. Wyatt
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Frontiers Media S.A. 2024-07-01
Seri Bilgileri:	Frontiers in Immunology
Konular:	HIV vaccine mRNA NFL SOSIP Env
Online Erişim:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1426232/full
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!

mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies

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