Shedding of Syndecan-1/CXCL1 Complexes by Matrix Metalloproteinase 7 Functions as an Epithelial Checkpoint of Neutrophil Activation

Although neutrophils play critical roles in innate immunity, in excess these cells cause severe tissue damage. Thus, neutrophil activation must be tightly regulated to prevent indiscriminant damage. Previously, we reported that mice lacking matrix metalloproteinase (MMP) 7 are protected from lung in...

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Détails bibliographiques
Publié dans:Am J Respir Cell Mol Biol
Auteurs principaux: Gill, Sean E., Nadler, Samuel T., Li, Qinglang, Frevert, Charles W., Park, Pyong Woo, Chen, Peter, Parks, William C.
Format: Artigo
Langue:Inglês
Publié: American Thoracic Society 2016
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4979362/
https://ncbi.nlm.nih.gov/pubmed/26934670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0193OC
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